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A recent post-hoc analysis of the 52-week, open-label extension phases of BIPARK I and II compared the longer-term outcome of subjects with a fluctuation history of 2 years or less (n = 227) between those who had received opicapone vs placebo in the initial double-blind phase of the trial

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In humans, lower levels of the de novo NAD + synthesis precursor Trp have been observed in blood samples of PD patients, indicating disruption of the kynurenine pathway 276,277

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